The effects of sevoflurane and subsequent administration of diltiazem on intrapulmonary shunt and oxygenation were studied in pentobarbital anesthetized dogs. After inhalation of 1MAC of sevoflurane and subsequent intravenous administration of
clinicaldose of diltiazem (loading dose 0.2 mg/kg, maintenance dose 0.01 mg/kg/min), there were no changes in cardiac output, arterial oxygen tension, mixed venous oxygen tension, oxygen transport, oxygen consumption, intrapulmonary shunt ratio,
pulmonary vascular resistance, alveolar-arterial oxygen difference. After intravenous administration of diltiazem with bolus (0.4 mg/kg) and maintenance dose (0.02 mg/kg/min), pulmonary vascular resistance was significantly decreased (p<0.05) but
the
other parameters indicating pulmonaruy hemodynamics and oxygenation were unchanged.
These results suggest that concomittent use of the two classes of drugs is not induce significant changes in pulmonary hemodynamic and oxygenation, and can be used safely in patient with normal cardiopulmonary function when clinical concentration
of
both were used.
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